Order Warfarin (generic Coumadin)

Information to have about Warfarin (Generic Equivalent to Coumadin) ..

What is Warfarin (Generic Coumadin) and what are its uses?
How does Warfarin (Generic Coumadin) treat?
Dosage: How should you take Warfarin (Generic Coumadin)?
Effect of other drugs consumed with Warfarin (Generic Coumadin)
What should you watch for while taking Warfarin (Generic Coumadin)?
Possible Side effects of Warfarin (Generic Coumadin)

Order Warfarin - Generic Equivalent to Coumadin
Category:	Blood Thinner
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What is Warfarin (Generic Coumadin) and what are its uses?

Coumadin (Warfarin) is an anticoagulant.

Coumadin helps to treat or prevent clots in the veins, arteries, lungs, or heart.

Coumadin stops clots from forming or getting bigger, and lets the body naturally dissolve the blood clots. Sometimes Coumadin is called a blood thinner because you may bleed more easily while taking it; however, Coumadin does not actually thin the blood.

How does Warfarin (Generic Coumadin) treat?

Coumadin tablets contain the active ingredient warfarin sodium, which is a type of medicine called an anticoagulant. Coumadin is used to stop blood clots forming within the blood vessels.

Blood clots normally only form to stop bleeding that has occurred as a result of injury to the tissues. The clotting process is complicated and begins when blood cells called platelets clump together at the site of damage and produce chemicals that activate clotting factors in the blood. Clotting factors are proteins that are produced by the liver. Vitamin K is essential for their production. The activated clotting factors cause a protein called fibrin to be converted into another called fibrinogen. Fibrinogen binds the platelets together, forming a blood clot. This is the body's natural way of repairing itself.

Sometimes, however, a blood clot can form abnormally within the blood vessels. This is known as a thrombus and can be dangerous because the clot may detach and travel in the bloodstream, where it becomes known as an embolus. The clot may eventually get lodged in a blood vessel, thereby blocking the blood supply to a vital organ such as the heart, brain or lungs. This is known as a thromboembolism.

Coumadin works by preventing the vitamin K dependent production of the clotting factors described above. Coumadin prevents the production of these clotting factors by inhibiting the action of vitamin K. Without these clotting factors fibrin cannot be converted into fibrinogen and blood clots are therefore less likely to occur. 

Dosage: How should you take Warfarin (Generic Coumadin)?

Take Coumadin tablets orally.

Coumadin is usually taken once a day. Swallow the tablets with a drink of water. Take your dose at the same time each day.

Do not take Coumadin more often than directed.

Adults
The usual starting dose of Coumadin tablets for adults are 2 to 5 milligrams per day. Individualized daily dosage adjustments are based on the results of tests that determine the amount of time it takes for the blood clotting process to begin.

A maintenance dose of 2 to 10 milligrams per day is satisfactory for most people. Your physician will determine the duration of treatment.

Older Adults
Low starting and maintenance doses of Coumadin are recommended for older people, as the drug tends to have a greater effect.

Children
Although Coumadin has been widely used in children below the age of 18, its safety and effectiveness for this purpose have not been formally established.

Have you skipped your Coumadin dose?
Avoid missing any dose of Coumadin. If you do miss a dose, take it as soon as you can that same day. If it is almost time for your next dose, take only that dose. Do not double doses of Coumadin, and do not take two doses in one day unless your health care professional tells you to; this can increase the risk of bleeding. If you miss a dose, record the date of the missed dose and tell your health care professional at your next visit. If you miss doses for two or more days, call your doctor for instructions.

If you take too much of Coumadin?
Incase of an overdose with Coumadin seek medical emergency immediately.

Symptoms of Coumadin overdose include

• bruising,
• small, broken blood vessels under the skin,
• excessive bleeding from cuts or wounds,
• bleeding from the gums,
• blood in the stools, urine, or vomit, and
• excessive menstrual bleeding in women.

Where should you store Coumadin?
Store Coumadin of the reach of children in a container that small children cannot open.

Store Coumadin at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Throw away any unused amount of Coumadin after the expiry date.

Available strengths of Coumadin
Coumadin tablets are available in the strengths of 1 mg, 2 mg and 5 mg. 

Effect of other drugs consumed with Warfarin (Generic Coumadin)

The following drugs may interact with Coumadin. They may increase or decrease the activity of Coumadin.

• agents that dissolve blood clots
• agents that lower cholesterol
• alcohol
• allopurinol
• amiodarone
• antibiotics or medicines for treating bacterial, fungal or viral infections
• antiinflammatory drugs, NSAIDs, such as ibuprofen
• aprepitant
• aspirin, acetaminophen (Tylenol)
• azathioprine
• barbiturate medicines for inducing sleep or treating seizures
• bosentan
• cimetidine
• cyclosporine
• disulfiram
• female hormones, including contraceptive or birth control pills
• fish oil (omega-3 fatty acids) supplements
• herbal products such as danshen, garlic, ginkgo, ginseng, green tea, or kava kava
• influenza virus vaccine
• male hormones
• medicines for some types of cancer
• certain medicines for heart rhythm problems
• certain medicines for high blood pressure
• quinidine, quinine
• seizure or epilepsy medicine such as carbamazepine, phenytoin, and valproic acid
• testolactone
• thyroid medicine
• tolterodine
• vitamin K (including vitamin, mineral, and food supplements that contain vitamin K)

Inform your health care professional about all other medicines that you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also inform your health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way Coumadin works.

Who should not take Coumadin?
Coumadin should not be used if you suffer from severe liver or kidney disease, hypertension, bacterial infection of the heart valves and the lining surrounding the heart (bacterial endocarditis) or peptic ulcers.

Coumadin is in the FDA pregnancy category X. This means that Coumadin is known to cause birth defects in an unborn baby and must not be taken during pregnancy. Do not take Coumadin if you are pregnant or could become pregnant during treatment. Consult your doctor immediately if you become pregnant while taking Coumadin.

Coumadin has not been detected in human breast milk. Talk to your doctor before taking warfarin if you are breast-feeding a baby.

Coumadin should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using Coumadin and inform your doctor or pharmacist immediately.

What should you watch for while taking Warfarin (Generic Coumadin)?

You should take extra care when participating in physical activities while taking Coumadin, as even minor injury may result in bleeding/bruising.

Because Coumadin prevents blood clotting, too much can increase your risk of bleeding. On the other hand, too little will not be effective at preventing clotting. It is therefore important that you have regular blood tests to monitor your blood clotting ability (INR) so that your dose can be altered if necessary. When first starting treatment this test should be daily or on alternate days, and as your INR becomes more stable the tests can be at longer intervals. Talk to your doctor about when your INR will need checking.

As Coumadin works by inhibiting the action of vitamin K, changes to your dietary intake of vitamin K can alter the effect of your warfarin. For this reason, avoid making sudden major changes to your diet, particularly your consumption of green tea, salad and green vegetables (e.g. broccoli, brussel sprouts, or spinach), which contain large amounts of vitamin K. Large amounts of green vegetables (more than 500g daily) can reduce the effect of warfarin and should be avoided. Changes to your consumption of fats and oils can also alter the effect of Coumadin, as vitamin K is a fat-soluble vitamin.

The effects of Coumadin can also be altered by other foods, for example soya bean products can reduce the effect of warfarin, and avocados and large amounts of ice cream (over a litre a day) have also been reported to have this effect. Cranberry juice should be avoided, as should large amounts of alcohol, as these may increase the effect of warfarin. Coumadin's effect can also be altered by sudden increases or decreases in your body weight. For these reasons you should avoid making sudden major changes to your diet during treatment with warfarin. For more information talk to your pharmacist.

Consult your doctor immediately if you experience any bruising, bleeding, dark stools, blood in the urine, vomiting, diarrhoea, fever or acute illness while taking this medicine, so that your INR can be checked.

Possible Side effects of Warfarin (Generic Coumadin)

Side effects of Coumadin that should be reported to your health care professional as soon as possible:

• signs and symptoms of bleeding such as bloody or black, tarry stools, red or dark-brown urine, spitting up blood or brown material that looks like coffee grounds, red spots on the skin, unusual bruising or bleeding from the eye, gums, or nose
• back or stomach pain
• chest pain; fast or irregular heartbeat (palpitations)
• difficulty breathing or talking, wheezing
• fever or chills
• heavy menstrual bleeding or vaginal bleeding
• nausea, vomiting
• painful, blue, or purple toes
• prolonged bleeding from cuts
• skin rash, itching or skin damage
• unusual swelling or sudden weight gain
• unusual tiredness or weakness
• yellowing of skin or eyes

Side effects of Coumadin that should be reported to your health care professional if they continue or are bothersome:

• diarrhea
• loss of appetite
• unusual hair loss